Abstract: Carcinogenic products like tobacco and areca nut which are widely consumed by the Indian population are major etiological factors which contribute to oral potentially malignant disorders which further lead to cancer. Some recent researches have led to detection of elevated fibrinogen degradation products in the plasma of patients with oral potentially malignant disorders and this has provided a new insight into their early diagnosis.  Objectives: To detect the plasma FDP values in individuals with habit of tobacco and areca nut and in normal subjects without any habits, and to compare them so as to assess the risk at preliminary stage. Study Design: This study comprised of 30 subjects with habit of tobacco and areca nut and 30 normal subjects without any habits. The subjects were evaluated for plasma FDP levels using immunoturbidimetric assay. Results: The plasma FDP in subjects with habit of tobacco and areca nut when compared with normal subjects showed increased levels (p = 0.029). Conclusions: Since fibrinogen degradation product levels increase in subjects with chronic habit of carcinogenic product consumption, this test can be used to determine the risk of developing oral potentially malignant disorders in such patients. 

Keywords: Arecanut, Fibrinogen Degradation products, Leukoplakia, Oral premalignant lesions, Oral submucous fibrosis, Tobacco.
Title: Utility of Plasma Fibrinogen Degradation Product Levels in the Assessment of Risk of Developing Oral Potentially Malignant Disorders in Subjects with Habit of Tobacco and Areca Nut Consumption
Author: Ruchi Sharma, Ashok Vikey, Shradha Jaiswal, Bhupesh Bagulkar, Atul Bhat, Nayan Bharadwaj
ISSN 2394-966X
International Journal of Novel Research in Life Sciences
Novelty Journals
 

Abstract: Sesame (Sesamum indicum L.) is generally considered to be a self-pollinated crop. Information about the out-crossing rate of Ethiopian sesame is not known. The aim of this study was to obtain reliable estimates of the amount and variation of out-crossing in Ethiopian sesame. Natural out-crossing was estimated in 47 sesame landraces representing the existing homeland collections and 3 released sesame varieties. Ten PCR based molecular markers, Simple Sequence Repeats (SSRs) have been used to estimate the out-crossing percentage based on the equilibrium inbreeding coefficient (Fe) under partial selfing. The Polymorphism Information Contents (PICs) of the markers ranged from 0.393 to 0.820, which indicates the highly informative nature of the SSRs reported here. The observed heterozygosity (Ho) for landraces and cultivars ranged from 0.060 to 0.440 and 0.120 to 0.260, with a mean of 0.234 and 0.193, respectively, indicating the existence of higher heterozygosity within the landraces than cultivars. Landraces also showed higher diversity compared to the cultivars in terms of Nei’s average genetic diversity of 0.377 compared with 0.305, respectively. High outcrossing of 45% and 46.4% have been estimated for landraces and cultivars, respectively, indicating both landraces and cultivars are not lines but line mixtures and segregants of past out-crossing results. Existence of high out-crossing rate among the landraces is a good starting point for sesame breeding, germplasm management and conservation in Ethiopia.

Keywords: Matting system, Molecular markers; Out-crossing, Sesame, Sesamum indicum L, SSR.
Title: Estimation of Outcrossing Rate in Ethiopian Sesame (Sesamum indicum L.) using SSR Markers
Author: Daniel Endale Gebremichael
ISSN 2394-966X
International Journal of Novel Research in Life Sciences
Novelty Journals

Abstract: Recent exciting discoveries place dentists at the forefront of engaging their patients in potentially life-saving therapies derived from a patient’s own stem cells located in deciduous and permanent teeth. With appropriate biochemical signals stem cells can be transformed into desirable cells. The idea behind this article is to shortly review the obtained literature on stem cell with respect to their properties, types and advantages of dental stem cells. Emphasis has been given to the possibilities of stem cell therapy in the oral and maxillofacial region including regeneration of tooth and craniofacial defects.

Keywords: Cryopreservation, Dental follicle embryonic stem cells, Pluripotent stem cells, Periodontal and Craniofacial defect.
Title: Stem Cells: Emerging Therapeutic Aids in Dental and Maxillofacial Surgery: A Review
Author: Mishra Abhishek, Maria Anisha, Tiwari Mala
ISSN 2394-966X
International Journal of Novel Research in Life Sciences
Novelty Journals
 

Abstract: Sesame (Sesamum indicum L.) is an important oil crop in Ethiopia. Despite its importance in the country, there are constraints that need to be addressed through scientific research. The major constraints are lack of improved varieties, low yield of landrace cultivars, indeterminate flowering nature and shattering of capsules at maturity, insects, diseases, heat and drought. Conventional sesame breeding efforts started in the late 1960s, and since then a total of 26 varieties have been developed and released. The use of molecular marker technology in sesame breeding is a new occurrence in Ethiopia. However, there have been efforts on the use of molecular techniques to complement and hasten the conventional sesame breeding. Two PCR-based molecular markers have been developed. Shattering is the number one cause of yield loss in sesame. Hybridization and recently, induced mutation are being employed to find solution to seed shattering.
Keywords: Conventional breeding, Indeterminate flowering, Molecular Markers, Seed shatteing, Sesame, Sesamum indicum.
Title: Sesame (Sesamum indicum L.)Breeding in Ethiopia
Author: Daniel Endale Gebremichael
ISSN 2394-966X
International Journal of Novel Research in Life Sciences
Novelty Journals