Vol 7 Issue 2 May 2020-August 2020
O.V. Ikpeazu, I.E. Otuokere, K.K.Igwe
Abstract: Trimethoprim is an antibiotic that is primarily used in the treatment of urinary tract infections. Continuous variation method was applied in the calculation of stability constant of trimethoprim-Zn(II) complex depending on the theoretical explanation of the stoichiometry. The formation of Zn(II) complex with trimethoprim was studied colorimetrically at an absorption maximum of 630 nm at 25, 30, 35 and 40 oC. The data showed that Zn(II) and trimethoprim combine in the molar ratio of 1:1 at pH 7.4 with ionic strength maintained using 0.1M KNO3. Calculated stability constants values were 8.13 x 106, 9.21 x 105, 4.47 x 105 and 4.52 x 104 at 25, 30, 35 and 40 oC respectively. Calculated ∆GƟ for the complex were -3.94 x 104, -3.46 x 104, -3.33 x 104 and -2.79 x 104 at 25, 30, 35 and 40 oC respectively. The stability constant results suggested that trimethoprim used in the study is a potent chelating agent and can be an efficient antidote in the therapy of Zn(II) overload or poisoning.
Keywords: Absorbance, colorimetric, complex, stability constant, trimethoprim, zinc.
Title: Determination of Stability Constant of Trimethoprim-Zn(II) complex at Different Temperatures by Continuous Variation Method
Author: O.V. Ikpeazu, I.E. Otuokere, K.K.Igwe
International Journal of Novel Research in Physics Chemistry & Mathematics